Found: The dial in the brain that controls the immune system

{
  "by": "andreareina",
  "descendants": 4,
  "id": 40243417,
  "kids": [
    40243718,
    40244904,
    40245202
  ],
  "score": 45,
  "time": 1714703500,
  "title": "Found: The dial in the brain that controls the immune system",
  "type": "story",
  "url": "https://www.nature.com/articles/d41586-024-01259-2"
}

{
  "author": "Giorgia Guglielmi",
  "date": "2024-05-01T00:00:00.000Z",
  "description": "Scientists identify the brain cells that regulate inflammation, and pinpoint how they keep tabs on the immune response.",
  "image": "https://media.nature.com/lw1200/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_27034294.jpg",
  "logo": "https://logo.clearbit.com/nature.com",
  "publisher": "Nature",
  "title": "Found: the dial in the brain that controls the immune system",
  "url": "https://www.nature.com/articles/d41586-024-01259-2"
}

{
  "url": "https://www.nature.com/articles/d41586-024-01259-2",
  "title": "Found: the dial in the brain that controls the immune system",
  "description": "Scientists identify the brain cells that regulate inflammation, and pinpoint how they keep tabs on the immune response. Scientists identify the brain cells that regulate inflammation, and pinpoint how they keep tabs on the immune response.",
  "links": [
    "https://www.nature.com/articles/d41586-024-01259-2"
  ],
  "image": "https://media.nature.com/lw1200/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_27034294.jpg",
  "content": "<div>\n                    <article>\n<div>\n        <div>\n            <ul>\n                <li><span>NEWS</span></li>\n                <li>01 May 2024</li>\n            </ul>\n            <div>\n                <p>\n                    Scientists identify the brain cells that regulate inflammation, and pinpoint how they keep tabs on the immune response.\n                </p>\n            </div>\n        </div>\n            <div>\n                <p><span>By</span></p><ul>\n        <li><a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2#author-0\">\n                Giorgia Guglielmi</a><sup><a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2#Aff0\">0</a></sup></li>\n</ul>\n<div>\n    <ol>\n            <li>\n                    <span>Giorgia Guglielmi</span>\n                    <ol>\n                        <li>\n                            <p>Giorgia Guglielmi is a science journalist in Basel, Switzerland.</p>\n                        </li>\n                    </ol>\n                    <div>\n                            <div><p><a target=\"_blank\" href=\"https://www.nature.com/search?author=Giorgia+Guglielmi\">View author publications</a></p></div>\n                            <div>\n                                <p>You can also search for this author in <span><a target=\"_blank\" href=\"http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&amp;term=Giorgia+Guglielmi\">PubMed</a>\n                                    <span> </span><a target=\"_blank\" href=\"https://scholar.google.co.uk/scholar?as_q=&amp;btnG=Search+Scholar&amp;as_sauthors=%22Giorgia%2BGuglielmi%22\">Google Scholar</a>\n                                    </span></p>\n                            </div>\n                       </div>\n            </li>\n    </ol>\n</div>\n            </div>\n    <div>\n        <ul>\n    <li>\n        <a target=\"_blank\" href=\"https://twitter.com/intent/tweet?text=Found%3A+the+dial+in+the+brain+that+controls+the+immune+system&amp;url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">\n            <span>Twitter</span>\n        </a>\n    </li>\n    <li>\n        <a target=\"_blank\" href=\"http://www.facebook.com/sharer.php?u=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">\n            <span>Facebook</span>\n        </a>\n    </li>\n    <li>\n        <a target=\"_blank\" href=\"mailto:?subject=Found:%20the%20dial%20in%20the%20brain%20that%20controls%20the%20immune%20system&amp;body=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">\n            <span>Email</span>\n        </a>\n    </li>\n</ul>\n    </div>\n</div>\n                    <div>\n            <p>\n                <a target=\"_blank\" href=\"https://wayf.springernature.com/?redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">\n                    <span>Access through your institution</span>\n                </a>\n            </p>\n                <div>\n                    <p><a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2#access-options\">\n                        <span>Buy or subscribe</span>\n                    </a>\n                </p></div>\n        </div>\n                    <p>Scientists have long known that <a target=\"_blank\" href=\"https://doi.org/10.1038/d41586-023-00509-z\">the brain plays a part in the immune system</a> — but how it does so has been a mystery. Now, scientists have identified cells in the brainstem that sense <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-021-01396-y\">immune cues from the periphery of the body</a> and act as master regulators of the body’s <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-00871-6\">inflammatory response</a>.</p>\n                    <div>\n                        <h2 id=\"access-options\">Access options</h2>\n        <div>\n            <p>\n                <a target=\"_blank\" href=\"https://wayf.springernature.com/?redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">\n                    <span>Access through your institution</span>\n                </a>\n            </p>\n        </div>\n    <section><div>\n      <p>\n        Access Nature and 54 other Nature Portfolio journals\n      </p>\n      <p>\n        Get Nature+, our best-value online-access subscription\n      </p>\n      <div>\n        <p>\n          <span>$32.99<span> / 30 days</span></span>\n        </p>\n        <p>cancel any time</p>\n      </div>\n      <div>\n        <p><a target=\"_blank\" href=\"https://shop-amers.nature.com/products/plus/?region=US\"><span>Learn more</span></a>\n      </p></div>\n    </div><div>\n      <p>Subscribe to this journal</p>\n      <p>\n        Receive 51 print issues and online access\n      </p>\n    <div>\n      <p>$199.00 per year</p>\n      <p>only $3.90 per issue</p>\n    </div>\n    <div>\n      <p><a target=\"_blank\" href=\"https://www.nature.com/nature/subscribe\"><span>Learn more</span></a>\n    </p></div>\n    </div><div>\n      <p>Rent or buy this article</p>\n      <p>Prices vary by article type</p>\n      <p><span>from</span>$1.95</p>\n      <p><span>to</span>$39.95</p>\n      <div>\n        <p><a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2.epdf?no_publisher_access=1&amp;r3_referer=nature\"><span>Learn more</span></a>\n      </p></div>\n    </div><p>Prices may be subject to local taxes which are calculated during checkout</p></section>\n    <h3>Additional access options:</h3>\n    <ul>\n        <li>\n            <a target=\"_blank\" href=\"https://idp.nature.com/authorize/natureuser?client_id=grover&amp;redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">Log in</a>\n        </li>\n        <li>\n            <a target=\"_blank\" href=\"https://www.springernature.com/gp/librarians/licensing/license-options\">Learn about institutional subscriptions</a>\n        </li>\n        <li>\n            <a target=\"_blank\" href=\"https://support.nature.com/en/support/home\">Read our FAQs</a>\n        </li>\n        <li>\n            <a target=\"_blank\" href=\"https://www.springernature.com/gp/contact\">Contact customer support</a>\n        </li>\n    </ul>\n                    </div>\n                <p><em>doi: https://doi.org/10.1038/d41586-024-01259-2</em></p>\n            <div><h2 id=\"Bib1\">References</h2><div><ol><li><p>Jin, H., Li, M., Jeong, E., Castro-Martinez, F. &amp; Zuker, C. S. <i>Nature</i> https://doi.org/10.1038/s41586-024-07469-y (2024).</p><p><a target=\"_blank\" href=\"https://doi.org/10.1038%2Fs41586-024-07469-y\">Article</a> \n    <a target=\"_blank\" href=\"http://scholar.google.com/scholar_lookup?&amp;title=&amp;journal=Nature&amp;doi=10.1038%2Fs41586-024-07469-y&amp;publication_year=2024&amp;author=Jin%2CH.&amp;author=Li%2CM.&amp;author=Jeong%2CE.&amp;author=Castro-Martinez%2CF.&amp;author=Zuker%2CC.%20S.\">\n                    Google Scholar</a> \n                </p></li></ol><p><a target=\"_blank\" href=\"https://citation-needed.springer.com/v2/references/10.1038/d41586-024-01259-2?format=refman&amp;flavour=references\">Download references</a></p></div></div>\n                <div>\n                    <p><a target=\"_blank\" href=\"https://s100.copyright.com/AppDispatchServlet?title=Found%3A%20the%20dial%20in%20the%20brain%20that%20controls%20the%20immune%20system&amp;author=Giorgia%20Guglielmi&amp;contentID=10.1038%2Fd41586-024-01259-2&amp;copyright=Springer%20Nature%20Limited&amp;publication=0028-0836&amp;publicationDate=2024-05-01&amp;publisherName=SpringerNature&amp;orderBeanReset=true\">Reprints and permissions</a></p>\n                </div>\n                <h2 id=\"related-articles\">Related Articles</h2>\n    <ul>\n            <li>\n                <p>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-023-00509-z\">\n                            <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_24096670.jpg\" />\n                        Your brain could be controlling how sick you get — and how you recover\n                    </a>\n                </p>\n            </li>\n            <li>\n                <p>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-022-01502-8\">\n                            <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_24045344.jpg\" />\n                        Guardians of the brain: how a special immune system protects our grey matter\n                    </a>\n                </p>\n            </li>\n            <li>\n                <p>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-00169-7\">\n                            <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_26671374.jpg\" />\n                        Can autoimmune diseases be cured? Scientists see hope at last\n                    </a>\n                </p>\n            </li>\n            <li>\n                <p>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-023-00584-2\">\n                            <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_24096666.jpg\" />\n                        Anxiety can be created by the body, mouse heart study suggests\n                    </a>\n                </p>\n            </li>\n    </ul>\n                <h2 id=\"subjects\">Subjects</h2>\n    <ul>\n            <li>\n                <a target=\"_blank\" href=\"https://www.nature.com/subjects/brain\">Brain</a>\n            </li>\n            <li>\n                <a target=\"_blank\" href=\"https://www.nature.com/subjects/immunology\">Immunology</a>\n            </li>\n            <li>\n                <a target=\"_blank\" href=\"https://www.nature.com/subjects/neuroscience\">Neuroscience</a>\n            </li>\n    </ul>\n            <section>\n    <h2 id=\"tablist-heading\">Latest on:</h2>\n    <div>\n            <div>\n                            <article>\n                                <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-025-01569-z\">\n                                        <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-025-01569-z/d41586-025-01569-z_51001380.jpg\" alt=\"Brain drugs can now cross the once impenetrable blood–brain barrier\" />\n                                    <p>Brain drugs can now cross the once impenetrable blood–brain barrier</p>\n                                    <p><span>News Feature</span> <span>28 MAY 25</span></p>\n                                </a>\n                            </article>\n                            <article>\n                                <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-025-01655-2\">\n                                        <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-025-01655-2/d41586-025-01655-2_51028546.jpg\" alt=\"How the brain spies on the gut: with help from newfound immune cells\" />\n                                    <p>How the brain spies on the gut: with help from newfound immune cells</p>\n                                    <p><span>News</span> <span>28 MAY 25</span></p>\n                                </a>\n                            </article>\n                            <article>\n                                <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-025-01494-1\">\n                                        <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-025-01494-1/d41586-025-01494-1_50993750.jpg\" alt=\"Time-management skills I honed as a PhD student now serve me well in industry\" />\n                                    <p>Time-management skills I honed as a PhD student now serve me well in industry</p>\n                                    <p><span>Career Column</span> <span>27 MAY 25</span></p>\n                                </a>\n                            </article>\n                    </div>\n            <div>\n                            <article>\n                                <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-025-01722-8\">\n                                        <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-025-01722-8/d41586-025-01722-8_51041762.jpg\" alt=\"Cancer fighting CAR-T cells show promising results for hard-to-treat tumours\" />\n                                    <p>Cancer fighting CAR-T cells show promising results for hard-to-treat tumours</p>\n                                    <p><span>News</span> <span>02 JUN 25</span></p>\n                                </a>\n                            </article>\n                            <article>\n                                <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-025-01687-8\">\n                                        <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-025-01687-8/d41586-025-01687-8_51032354.jpg\" alt=\"Black Death bacterium has become less lethal after genetic tweak\" />\n                                    <p>Black Death bacterium has become less lethal after genetic tweak</p>\n                                    <p><span>News</span> <span>29 MAY 25</span></p>\n                                </a>\n                            </article>\n                            <article>\n                                <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-025-01655-2\">\n                                        <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-025-01655-2/d41586-025-01655-2_51028546.jpg\" alt=\"How the brain spies on the gut: with help from newfound immune cells\" />\n                                    <p>How the brain spies on the gut: with help from newfound immune cells</p>\n                                    <p><span>News</span> <span>28 MAY 25</span></p>\n                                </a>\n                            </article>\n                    </div>\n            <div>\n                            <article>\n                                <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-025-01653-4\">\n                                        <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-025-01653-4/d41586-025-01653-4_51041572.jpg\" alt=\"CRISPR helps to show why a boy felt no pain\" />\n                                    <p>CRISPR helps to show why a boy felt no pain</p>\n                                    <p><span>Research Highlight</span> <span>30 MAY 25</span></p>\n                                </a>\n                            </article>\n                            <article>\n                                <a target=\"_blank\" href=\"https://www.nature.com/articles/s41586-025-08953-9\">\n                                        <img src=\"https://media.nature.com/w140h79/springer-static/image/art%3A10.1038%2Fs41586-025-08953-9/MediaObjects/41586_2025_8953_Fig1_HTML.png\" alt=\"The history and future of resting-state functional magnetic resonance imaging\" />\n                                    <p>The history and future of resting-state functional magnetic resonance imaging</p>\n                                    <p><span>Review Article</span> <span>28 MAY 25</span></p>\n                                </a>\n                            </article>\n                            <article>\n                                <a target=\"_blank\" href=\"https://www.nature.com/articles/s41586-025-09013-y\">\n                                        <img src=\"https://media.nature.com/w140h79/springer-static/image/art%3A10.1038%2Fs41586-025-09013-y/MediaObjects/41586_2025_9013_Fig1_HTML.png\" alt=\"Astrocyte morphogenesis requires self-recognition\" />\n                                    <p>Astrocyte morphogenesis requires self-recognition</p>\n                                    <p><span>Article</span> <span>28 MAY 25</span></p>\n                                </a>\n                            </article>\n                    </div>\n    </div>\n</section>\n            <div>\n        <div>\n            <h2>\n                <img src=\"https://www.nature.com/static/images/logos/nature-careers-logo-f6ff1c1c64.svg\" alt=\"Nature Careers\" />\n            </h2>\n        </div>\n        <h3>\n            <a target=\"_blank\" href=\"https://www.nature.com/naturecareers/\">Jobs\n            </a>\n        </h3>\n        <ul>\n                <li>\n                    <div>\n                        <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12840090/tier-2-canada-research-chair-faculty-position-in-supercomputing-and-high-performance-computing/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">Tier 2 Canada Research Chair Faculty Position in Supercomputing and High-Performance Computing</a></h4>\n                        <div>\n                            <p>Tier 2 Canada Research Chair Faculty Position in Supercomputing and High-Performance Computing Department of Electrical and Computer Engineering.</p>\n                            <p>Kingston, Ontario (CA)</p>\n                            <p>Smith Engineering - Queen's University</p>\n                        </div>\n                    </div>\n                        <p><img src=\"https://www.nature.com/naturecareers/getasset/68c9014f-2c6e-49fa-bdde-90ebba866115/\" />\n                        </p>\n                </li>\n                <li>\n                    <div>\n                        <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12839995/faculty-positions/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">Faculty Positions</a></h4>\n                        <div>\n                            <p>Faculty Positions in Physics and Astronomy National Tsing Hua University, Taiwan (located in Hsinchu – the heart of Taiwan’s science and tech hub)</p>\n                            <p>Hsinchu,Taiwan (TW)</p>\n                            <p>The Department of Physics and Institute of Astronomy at National Tsing Hua University, Taiwan</p>\n                        </div>\n                    </div>\n                        <p><img src=\"https://www.nature.com/naturecareers/getasset/f7df8eba-7c1f-4976-9314-a31ec5a82ac8/\" />\n                        </p>\n                </li>\n                <li>\n                    <div>\n                        <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12837179/seeking-excellent-young-scientists-fund-overseas-and-academic-positions-at-all-levels/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">Seeking Excellent Young Scientists Fund (overseas) and academic positions at all levels</a></h4>\n                        <div>\n                            <p>Seeking Excellent Young Scientists Fund (overseas), Full Professors, Associate Professors, Assistant Professors, Postdoctoral Associate.</p>\n                            <p>Beijing, China</p>\n                            <p>State Key Laboratory of Optoelectronic Materials and Devices at the Institute of Semiconductors, CAS</p>\n                        </div>\n                    </div>\n                        <p><img src=\"https://www.nature.com/naturecareers/getasset/9f6b4612-18af-4dea-9783-f418c7ebb304/\" />\n                        </p>\n                </li>\n                <li>\n                    <div>\n                        <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12840030/faculty-positions/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">Faculty Positions</a></h4>\n                        <div>\n                            <p>Zhejiang (CN)</p>\n                            <p>Zhejiang University-University of Edinburgh Institute Haining, China</p>\n                        </div>\n                    </div>\n                        <p><img src=\"https://www.nature.com/naturecareers/getasset/bc6d31e2-8ed1-47ed-a3ea-24423eb19f20/\" />\n                        </p>\n                </li>\n                <li>\n                    <div>\n                        <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12839971/junior-professorship-position-f-m-d-in-single-cell-systems-biology/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">junior professorship position (f/m/d) in Single-Cell Systems Biology</a></h4>\n                        <div>\n                            <p>The Julius-Maximilians-University Würzburg, Faculty of Medicine is offering one junior professorship position (f/m/d) in Single-Cell Systems Biology.</p>\n                            <p>Würzburg (Stadt), Bayern (DE)</p>\n                            <p>Julius-Maximilians-University Würzburg - Faculty of Medicine</p>\n                        </div>\n                    </div>\n                        <p><img src=\"https://www.nature.com/naturecareers/getasset/a7ac02b2-92bf-4044-883a-b8108c08405f/\" />\n                        </p>\n                </li>\n        </ul>\n            </div>\n                    </article>\n                </div>",
  "author": "Guglielmi, Giorgia",
  "favicon": "https://www.nature.com/static/images/favicons/nature/favicon.ico",
  "source": "nature.com",
  "published": "2024-05-01",
  "ttr": 117,
  "type": "article"
}