Found: The dial in the brain that controls the immune system

https://www.nature.com/articles/d41586-024-01259-2

Scientists have long known that the brain plays a part in the immune system — but how it does so has been a mystery. Now, scientists have identified cells in the brainstem that sense immune cues from the periphery of the body and act as master regulators of the body’s inflammatory response.

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doi: https://doi.org/10.1038/d41586-024-01259-2

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"title": "Found: The dial in the brain that controls the immune system",
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"author": "Giorgia Guglielmi",
"date": "2024-05-01T00:00:00.000Z",
"description": "Scientists identify the brain cells that regulate inflammation, and pinpoint how they keep tabs on the immune response.",
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"title": "Found: the dial in the brain that controls the immune system",
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{
"url": "https://www.nature.com/articles/d41586-024-01259-2",
"title": "Found: the dial in the brain that controls the immune system",
"description": "Scientists identify the brain cells that regulate inflammation, and pinpoint how they keep tabs on the immune response. Scientists identify the brain cells that regulate inflammation, and pinpoint how they keep tabs on the immune response.",
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"content": "<div>\n <article>\n <p>Scientists have long known that <a target=\"_blank\" href=\"https://doi.org/10.1038/d41586-023-00509-z\">the brain plays a part in the immune system</a> — but how it does so has been a mystery. Now, scientists have identified cells in the brainstem that sense <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-021-01396-y\">immune cues from the periphery of the body</a> and act as master regulators of the body’s <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-00871-6\">inflammatory response</a>.</p>\n <div>\n <h2 id=\"access-options\">Access options</h2>\n <section><div>\n <p>\n Access Nature and 54 other Nature Portfolio journals\n </p>\n <p>\n Get Nature+, our best-value online-access subscription\n </p>\n <div>\n <p>\n <span>$32.99<span> / 30 days</span></span>\n </p>\n <p>cancel any time</p>\n </div>\n </div><div>\n <p>Subscribe to this journal</p>\n <p>\n Receive 51 print issues and online access\n </p>\n <div>\n <p>$199.00 per year</p>\n <p>only $3.90 per issue</p>\n </div>\n </div><div>\n <p>Rent or buy this article</p>\n <p>Prices vary by article type</p>\n <p><span>from</span>$1.95</p>\n <p><span>to</span>$39.95</p>\n </div><p>Prices may be subject to local taxes which are calculated during checkout</p></section>\n <h3>Additional access options:</h3>\n <ul>\n <li>\n <a target=\"_blank\" href=\"https://idp.nature.com/authorize/natureuser?client_id=grover&amp;redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">Log in</a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.springernature.com/gp/librarians/licensing/license-options\">Learn about institutional subscriptions</a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://support.nature.com/en/support/home\">Read our FAQs</a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.springernature.com/gp/contact\">Contact customer support</a>\n </li>\n </ul>\n </div>\n <p><em>doi: https://doi.org/10.1038/d41586-024-01259-2</em></p>\n <div><h2 id=\"Bib1\">References</h2></div>\n <h2 id=\"related-articles\">Related Articles</h2>\n <ul>\n <li>\n <p>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-023-00509-z\">\n <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_24096670.jpg\" />\n Your brain could be controlling how sick you get — and how you recover\n </a>\n </p>\n </li>\n <li>\n <p>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-022-01502-8\">\n <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_24045344.jpg\" />\n Guardians of the brain: how a special immune system protects our grey matter\n </a>\n </p>\n </li>\n <li>\n <p>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-00169-7\">\n <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_26671374.jpg\" />\n Can autoimmune diseases be cured? Scientists see hope at last\n </a>\n </p>\n </li>\n <li>\n <p>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-023-00584-2\">\n <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_24096666.jpg\" />\n Anxiety can be created by the body, mouse heart study suggests\n </a>\n </p>\n </li>\n </ul>\n <h2 id=\"subjects\">Subjects</h2>\n <ul>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/subjects/brain\">Brain</a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/subjects/immunology\">Immunology</a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/subjects/neuroscience\">Neuroscience</a>\n </li>\n </ul>\n <section>\n <h2 id=\"tablist-heading\">Latest on:</h2>\n <ul>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2#latest-content-0-container\">Brain</a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2#latest-content-1-container\">Immunology</a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2#latest-content-2-container\">Neuroscience</a>\n </li>\n </ul>\n <section>\n <ul>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-026-00768-6\">\n <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-026-00768-6/d41586-026-00768-6_52166590.jpg\" />\n <p>Memory loss is fuelled by gut microbes in ageing mice</p>\n <p><span>News</span> <span>11 MAR 26</span></p>\n </a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-026-00756-w\">\n <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-026-00756-w/d41586-026-00756-w_52158030.jpg\" />\n <p>Scientists revive activity in frozen mouse brains for the first time</p>\n <p><span>News</span> <span>11 MAR 26</span></p>\n </a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-026-00747-x\">\n <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-026-00747-x/d41586-026-00747-x_52143478.jpg\" />\n <p>These brain cells clear proteins that contribute to Alzheimer’s</p>\n <p><span>News</span> <span>05 MAR 26</span></p>\n </a>\n </li>\n </ul>\n </section>\n <section>\n <ul>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/s41586-026-10248-6\">\n <img src=\"https://media.nature.com/w140h79/springer-static/image/art%3A10.1038%2Fs41586-026-10248-6/MediaObjects/41586_2026_10248_Fig1_HTML.png\" />\n <p>B cell imprinting in children impairs antibodies to the haemagglutinin stalk</p>\n <p><span>Article</span> <span>11 MAR 26</span></p>\n </a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-026-00795-3\">\n <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-026-00795-3/d41586-026-00795-3_52166280.jpg\" />\n <p>Using mosquitoes to vaccinate bats could curb the spread of deadly diseases</p>\n <p><span>News</span> <span>11 MAR 26</span></p>\n </a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/s41586-026-10208-0\">\n <img src=\"https://media.nature.com/w140h79/springer-static/image/art%3A10.1038%2Fs41586-026-10208-0/MediaObjects/41586_2026_10208_Fig1_HTML.png\" />\n <p>Facile induction of immune tolerance by an interleukin-2–TGFβ surrogate agonist</p>\n <p><span>Article</span> <span>11 MAR 26</span></p>\n </a>\n </li>\n </ul>\n </section>\n <section>\n <ul>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-026-00492-1\">\n <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-026-00492-1/d41586-026-00492-1_52162860.jpg\" />\n <p>Gut microbes affect cognition during ageing</p>\n <p><span>News &amp; Views</span> <span>11 MAR 26</span></p>\n </a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-026-00768-6\">\n <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-026-00768-6/d41586-026-00768-6_52166590.jpg\" />\n <p>Memory loss is fuelled by gut microbes in ageing mice</p>\n <p><span>News</span> <span>11 MAR 26</span></p>\n </a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-026-00756-w\">\n <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-026-00756-w/d41586-026-00756-w_52158030.jpg\" />\n <p>Scientists revive activity in frozen mouse brains for the first time</p>\n <p><span>News</span> <span>11 MAR 26</span></p>\n </a>\n </li>\n </ul>\n </section>\n</section>\n <div>\n <div>\n <h2>\n <img src=\"https://www.nature.com/static/images/logos/nature-careers-logo-3c89275050.svg\" alt=\"Nature Careers\" />\n </h2>\n </div>\n <h3>\n <a target=\"_blank\" href=\"https://www.nature.com/naturecareers/\">Jobs\n </a>\n </h3>\n <ul>\n <li>\n <div>\n <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12856441/professor-of-integrated-immunology/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">Professor of Integrated Immunology</a></h4>\n <div>\n <p>The Department of Biology (D-BIOL; www.biol.ethz.ch) at ETH Zurich invites applications for the above-mentioned position.</p>\n <p>Zurich, Switzerland</p>\n <p>ETH Zurich</p>\n </div>\n </div>\n <p><img src=\"https://www.nature.com/naturecareers/getasset/13e74ea4-ed03-4199-8cd5-fcff08e64438/\" />\n </p>\n </li>\n <li>\n <div>\n <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12856437/phd-candidate-m-f-d-/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">PhD Candidate (m/f/d)</a></h4>\n <div>\n <p>In cooperation with the BMFTR funded I-CHECK-HEART Consortium</p>\n <p>Dortmund, Nordrhein-Westfalen (DE)</p>\n <p>Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V.</p>\n </div>\n </div>\n <p><img src=\"https://www.nature.com/naturecareers/getasset/e669a324-0f8f-4fce-9dc0-c454c03f467e/\" />\n </p>\n </li>\n <li>\n <p><img src=\"https://www.nature.com/naturecareers/getasset/a54e1688-cc0b-4a92-92cd-8d9e85615e82/\" />\n </p>\n </li>\n <li>\n <p><img src=\"https://www.nature.com/naturecareers/getasset/6d9a3c10-6d68-4bcf-b382-377813f6868b/\" />\n </p>\n </li>\n <li>\n <div>\n <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12856410/associate-or-senior-editor-nature-cancer/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">Associate or Senior Editor, Nature Cancer</a></h4>\n <div>\n <p>Job Title: Associate or Senior Editor, Nature Cancer Location: Beijing, Madrid, Nanjing or Shanghai - Hybrid working model   Applications Deadline:...</p>\n <p>Beijing, Madrid, Nanjing or Shanghai - Hybrid working model</p>\n <p>Springer Nature Ltd</p>\n </div>\n </div>\n <p><img src=\"https://www.nature.com/naturecareers/getasset/7387bab3-756d-4666-8199-d6e4d0b97d0f/\" />\n </p>\n </li>\n </ul>\n </div>\n </article>\n </div>",
"author": "Guglielmi, Giorgia",
"favicon": "https://www.nature.com/static/images/favicons/nature/favicon.ico",
"source": "nature.com",
"published": "2024-05-01",
"ttr": 82,
"type": "article"
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