Found: The dial in the brain that controls the immune system

{
  "by": "andreareina",
  "descendants": 4,
  "id": 40243417,
  "kids": [
    40243718,
    40244904,
    40245202
  ],
  "score": 45,
  "time": 1714703500,
  "title": "Found: The dial in the brain that controls the immune system",
  "type": "story",
  "url": "https://www.nature.com/articles/d41586-024-01259-2"
}

{
  "author": "Giorgia Guglielmi",
  "date": "2024-05-01T00:00:00.000Z",
  "description": "Scientists identify the brain cells that regulate inflammation, and pinpoint how they keep tabs on the immune response.",
  "image": "https://media.nature.com/lw1200/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_27034294.jpg",
  "logo": "https://logo.clearbit.com/nature.com",
  "publisher": "Nature",
  "title": "Found: the dial in the brain that controls the immune system",
  "url": "https://www.nature.com/articles/d41586-024-01259-2"
}

{
  "url": "https://www.nature.com/articles/d41586-024-01259-2",
  "title": "Found: the dial in the brain that controls the immune system",
  "description": "Scientists identify the brain cells that regulate inflammation, and pinpoint how they keep tabs on the immune response. Scientists identify the brain cells that regulate inflammation, and pinpoint how they keep tabs on the immune response.",
  "links": [
    "https://www.nature.com/articles/d41586-024-01259-2"
  ],
  "image": "https://media.nature.com/lw1200/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_27034294.jpg",
  "content": "<div>\n                    <article>\n<div>\n        <div>\n            <ul>\n                <li><span>NEWS</span></li>\n                <li>01 May 2024</li>\n            </ul>\n            <div>\n                <p>\n                    Scientists identify the brain cells that regulate inflammation, and pinpoint how they keep tabs on the immune response.\n                </p>\n            </div>\n        </div>\n            <div>\n                <ul>\n    By\n        <li><a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2#author-0\">\n                Giorgia Guglielmi</a><sup><a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2#Aff0\">0</a></sup></li>\n</ul>\n<div>\n    <ol>\n            <li>\n                    <span>Giorgia Guglielmi</span>\n                    <ol>\n                        <li>\n                            <p>Giorgia Guglielmi is a science journalist in Basel, Switzerland.</p>\n                        </li>\n                    </ol>\n                    <div>\n                            <div><p><a target=\"_blank\" href=\"https://www.nature.com/search?author=Giorgia+Guglielmi\">View author publications</a></p></div>\n                            <div>\n                                <p>You can also search for this author in <span><a target=\"_blank\" href=\"http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&amp;term=Giorgia+Guglielmi\">PubMed</a>\n                                    <span> </span><a target=\"_blank\" href=\"https://scholar.google.co.uk/scholar?as_q=&amp;btnG=Search+Scholar&amp;as_sauthors=%22Giorgia%2BGuglielmi%22\">Google Scholar</a>\n                                    </span></p>\n                            </div>\n                       </div>\n            </li>\n    </ol>\n</div>\n            </div>\n    <div>\n        <ul>\n    <li>\n        <a target=\"_blank\" href=\"https://twitter.com/intent/tweet?text=Found%3A+the+dial+in+the+brain+that+controls+the+immune+system&amp;url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">\n            <span>Twitter</span>\n        </a>\n    </li>\n    <li>\n        <a target=\"_blank\" href=\"http://www.facebook.com/sharer.php?u=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">\n            <span>Facebook</span>\n        </a>\n    </li>\n    <li>\n        <a target=\"_blank\" href=\"mailto:?subject=Found:%20the%20dial%20in%20the%20brain%20that%20controls%20the%20immune%20system&amp;body=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">\n            <span>Email</span>\n        </a>\n    </li>\n</ul>\n    </div>\n</div>\n                    <p>Scientists have long known that <a target=\"_blank\" href=\"https://doi.org/10.1038/d41586-023-00509-z\">the brain plays a part in the immune system</a> — but how it does so has been a mystery. Now, scientists have identified cells in the brainstem that sense <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-021-01396-y\">immune cues from the periphery of the body</a> and act as master regulators of the body’s <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-00871-6\">inflammatory response</a>.</p>\n                    <div>\n                        <h2 id=\"access-options\">Access options</h2>\n    <section><div>\n      <p>\n        Access Nature and 54 other Nature Portfolio journals\n      </p>\n      <p>\n        Get Nature+, our best-value online-access subscription\n      </p>\n      <div>\n        <p>\n          <span>$29.99<span> / 30 days</span></span>\n        </p>\n        <p>cancel any time</p>\n      </div>\n      <div>\n        <p><a target=\"_blank\" href=\"https://shop-amers.nature.com/products/plus\"><span>Learn more</span></a>\n      </p></div>\n    </div><div>\n      <p>Subscribe to this journal</p>\n      <p>\n        Receive 51 print issues and online access\n      </p>\n    <div>\n      <p>$199.00 per year</p>\n      <p>only $3.90 per issue</p>\n    </div>\n    <div>\n      <p><a target=\"_blank\" href=\"https://www.nature.com/nature/subscribe\"><span>Learn more</span></a>\n    </p></div>\n    </div><div>\n      <p>Rent or buy this article</p>\n      <p>Prices vary by article type</p>\n      <p><span>from</span>$1.95</p>\n      <p><span>to</span>$39.95</p>\n      <div>\n        <p><a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2.epdf?no_publisher_access=1&amp;r3_referer=nature\"><span>Learn more</span></a>\n      </p></div>\n    </div><p>Prices may be subject to local taxes which are calculated during checkout</p></section>\n    <h3>Additional access options:</h3>\n    <ul>\n        <li>\n            <a target=\"_blank\" href=\"https://idp.nature.com/authorize/natureuser?client_id=grover&amp;redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">Log in</a>\n        </li>\n        <li>\n            <a target=\"_blank\" href=\"https://www.springernature.com/gp/librarians/licensing/license-options\">Learn about institutional subscriptions</a>\n        </li>\n        <li>\n            <a target=\"_blank\" href=\"https://support.nature.com/en/support/home\">Read our FAQs</a>\n        </li>\n        <li>\n            <a target=\"_blank\" href=\"https://www.springernature.com/gp/contact\">Contact customer support</a>\n        </li>\n    </ul>\n                    </div>\n                <p><em>doi: https://doi.org/10.1038/d41586-024-01259-2</em></p>\n            <div><h2 id=\"Bib1\">References</h2><div><ol><li><p>Jin, H., Li, M., Jeong, E., Castro-Martinez, F. &amp; Zuker, C. S. <i>Nature</i> https://doi.org/10.1038/s41586-024-07469-y (2024).</p><p><a target=\"_blank\" href=\"https://doi.org/10.1038%2Fs41586-024-07469-y\">Article</a> \n    <a target=\"_blank\" href=\"http://scholar.google.com/scholar_lookup?&amp;title=&amp;journal=Nature&amp;doi=10.1038%2Fs41586-024-07469-y&amp;publication_year=2024&amp;author=Jin%2CH.&amp;author=Li%2CM.&amp;author=Jeong%2CE.&amp;author=Castro-Martinez%2CF.&amp;author=Zuker%2CC.%20S.\">\n                    Google Scholar</a> \n                </p></li></ol><p><a target=\"_blank\" href=\"https://citation-needed.springer.com/v2/references/10.1038/d41586-024-01259-2?format=refman&amp;flavour=references\">Download references</a></p></div></div>\n                <div>\n                    <p><a target=\"_blank\" href=\"https://s100.copyright.com/AppDispatchServlet?title=Found%3A%20the%20dial%20in%20the%20brain%20that%20controls%20the%20immune%20system&amp;author=Giorgia%20Guglielmi&amp;contentID=10.1038%2Fd41586-024-01259-2&amp;copyright=Springer%20Nature%20Limited&amp;publication=0028-0836&amp;publicationDate=2024-05-01&amp;publisherName=SpringerNature&amp;orderBeanReset=true\">Reprints and permissions</a></p>\n                </div>\n                <h2 id=\"related-articles\">Related Articles</h2>\n    <ul>\n            <li>\n                <p>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-023-00509-z\">\n                            <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_24096670.jpg\" />\n                        Your brain could be controlling how sick you get — and how you recover\n                    </a>\n                </p>\n            </li>\n            <li>\n                <p>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-022-01502-8\">\n                            <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_24045344.jpg\" />\n                        Guardians of the brain: how a special immune system protects our grey matter\n                    </a>\n                </p>\n            </li>\n            <li>\n                <p>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-00169-7\">\n                            <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_26671374.jpg\" />\n                        Can autoimmune diseases be cured? Scientists see hope at last\n                    </a>\n                </p>\n            </li>\n            <li>\n                <p>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-023-00584-2\">\n                            <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_24096666.jpg\" />\n                        Anxiety can be created by the body, mouse heart study suggests\n                    </a>\n                </p>\n            </li>\n    </ul>\n                <h2 id=\"subjects\">Subjects</h2>\n    <ul>\n            <li>\n                <a target=\"_blank\" href=\"https://www.nature.com/subjects/brain\">Brain</a>\n            </li>\n            <li>\n                <a target=\"_blank\" href=\"https://www.nature.com/subjects/immunology\">Immunology</a>\n            </li>\n            <li>\n                <a target=\"_blank\" href=\"https://www.nature.com/subjects/neuroscience\">Neuroscience</a>\n            </li>\n    </ul>\n            <section>\n    <h2 id=\"tablist-heading\">Latest on:</h2>\n    <div>\n            <div>\n                            <article>\n                                <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-025-00502-8\">\n                                        <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-025-00502-8/d41586-025-00502-8_50658100.jpg\" alt=\"How chronic stress warps decision-making\" />\n                                    <p>How chronic stress warps decision-making</p>\n                                    <p><span>News</span> <span>19 FEB 25</span></p>\n                                </a>\n                            </article>\n                            <article>\n                                <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-025-00456-x\">\n                                        <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-025-00456-x/d41586-025-00456-x_50640222.jpg\" alt=\"Migraine is more than a headache — a radical rethink offers hope to one billion people\" />\n                                    <p>Migraine is more than a headache — a radical rethink offers hope to one billion people</p>\n                                    <p><span>News Feature</span> <span>18 FEB 25</span></p>\n                                </a>\n                            </article>\n                            <article>\n                                <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-025-00454-z\">\n                                        <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-025-00454-z/d41586-025-00454-z_50653246.png\" alt=\"Could psychedelics be fine-tuned to relieve anxiety but skip the ‘trip’?\" />\n                                    <p>Could psychedelics be fine-tuned to relieve anxiety but skip the ‘trip’?</p>\n                                    <p><span>News &amp; Views</span> <span>18 FEB 25</span></p>\n                                </a>\n                            </article>\n                    </div>\n            <div>\n                            <article>\n                                <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-025-00528-y\">\n                                        <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-025-00528-y/d41586-025-00528-y_50663156.jpg\" alt=\"AI tool diagnoses diabetes, HIV and COVID from a blood sample\" />\n                                    <p>AI tool diagnoses diabetes, HIV and COVID from a blood sample</p>\n                                    <p><span>News</span> <span>20 FEB 25</span></p>\n                                </a>\n                            </article>\n                            <article>\n                                <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-025-00302-0\">\n                                        <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-025-00302-0/d41586-025-00302-0_50625390.png\" alt=\"Peptides from abnormal RNA processing in cancer offer an immunotherapy target\" />\n                                    <p>Peptides from abnormal RNA processing in cancer offer an immunotherapy target</p>\n                                    <p><span>News &amp; Views</span> <span>19 FEB 25</span></p>\n                                </a>\n                            </article>\n                            <article>\n                                <a target=\"_blank\" href=\"https://www.nature.com/articles/s41586-024-08552-0\">\n                                        <img src=\"https://media.nature.com/w140h79/springer-static/image/art%3A10.1038%2Fs41586-024-08552-0/MediaObjects/41586_2024_8552_Fig1_HTML.png\" alt=\"Tumour-wide RNA splicing aberrations generate actionable public neoantigens\" />\n                                    <p>Tumour-wide RNA splicing aberrations generate actionable public neoantigens</p>\n                                    <p><span>Article</span> <span>19 FEB 25</span></p>\n                                </a>\n                            </article>\n                    </div>\n            <div>\n                            <article>\n                                <a target=\"_blank\" href=\"https://www.nature.com/articles/s41586-024-08488-5\">\n                                        <img src=\"https://media.nature.com/w140h79/springer-static/image/art%3A10.1038%2Fs41586-024-08488-5/MediaObjects/41586_2024_8488_Fig1_HTML.png\" alt=\"An opponent striatal circuit for distributional reinforcement learning\" />\n                                    <p>An opponent striatal circuit for distributional reinforcement learning</p>\n                                    <p><span>Article</span> <span>19 FEB 25</span></p>\n                                </a>\n                            </article>\n                            <article>\n                                <a target=\"_blank\" href=\"https://www.nature.com/articles/s41586-024-08580-w\">\n                                        <img src=\"https://media.nature.com/w140h79/springer-static/image/art%3A10.1038%2Fs41586-024-08580-w/MediaObjects/41586_2024_8580_Fig1_HTML.png\" alt=\"A dual-pathway architecture for stress to disrupt agency and promote habit\" />\n                                    <p>A dual-pathway architecture for stress to disrupt agency and promote habit</p>\n                                    <p><span>Article</span> <span>19 FEB 25</span></p>\n                                </a>\n                            </article>\n                            <article>\n                                <a target=\"_blank\" href=\"https://www.nature.com/articles/s41586-024-08541-3\">\n                                        <img src=\"https://media.nature.com/w140h79/springer-static/image/art%3A10.1038%2Fs41586-024-08541-3/MediaObjects/41586_2024_8541_Fig1_HTML.png\" alt=\"Global modules robustly emerge from local interactions and smooth gradients\" />\n                                    <p>Global modules robustly emerge from local interactions and smooth gradients</p>\n                                    <p><span>Article</span> <span>19 FEB 25</span></p>\n                                </a>\n                            </article>\n                    </div>\n    </div>\n</section>\n            <div>\n        <div>\n            <h2>\n                <img src=\"https://www.nature.com/static/images/logos/nature-careers-logo-f6ff1c1c64.svg\" alt=\"Nature Careers\" />\n            </h2>\n        </div>\n        <h3>\n            <a target=\"_blank\" href=\"https://www.nature.com/naturecareers/\">Jobs\n            </a>\n        </h3>\n        <ul>\n                <li>\n                    <div>\n                        <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12837194/professor-associate-professor-assistant-professor-senior-lecturer-lecturer/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">Professor/Associate Professor/Assistant Professor/Senior Lecturer/Lecturer</a></h4>\n                        <div>\n                            <p>The School of Science and Engineering (SSE) at The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen) sincerely invites applications for mul...</p>\n                            <p>Shenzhen, China</p>\n                            <p>The Chinese University of Hong Kong, Shenzhen (CUHK Shenzhen)</p>\n                        </div>\n                    </div>\n                        <p><img src=\"https://www.nature.com/naturecareers/getasset/c33f297e-6a62-44cf-87d2-a6f220a7df99/\" />\n                        </p>\n                </li>\n                <li>\n                    <div>\n                        <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12837193/professor-associate-professor-assistant-professor-senior-lecturer-lecturer/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">Professor/Associate Professor/Assistant Professor/Senior Lecturer/Lecturer</a></h4>\n                        <div>\n                            <p>The School of Science and Engineering (SSE) at The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen) sincerely invites applications for mul...</p>\n                            <p>Shenzhen, China</p>\n                            <p>The Chinese University of Hong Kong, Shenzhen (CUHK Shenzhen)</p>\n                        </div>\n                    </div>\n                        <p><img src=\"https://www.nature.com/naturecareers/getasset/c33f297e-6a62-44cf-87d2-a6f220a7df99/\" />\n                        </p>\n                </li>\n                <li>\n                    <div>\n                        <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12837192/faculty-positions-at-sustech-department-of-biomedical-engineering/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">Faculty Positions at SUSTech Department of Biomedical Engineering</a></h4>\n                        <div>\n                            <p>We seek outstanding applicants for full-time tenure-track/tenured faculty positions. Positions are available for both junior and senior-level.</p>\n                            <p>Shenzhen, Guangdong, China</p>\n                            <p>Southern University of Science and Technology (Biomedical Engineering)</p>\n                        </div>\n                    </div>\n                        <p><img src=\"https://www.nature.com/naturecareers/getasset/2d8a9245-ef39-4585-96fc-ddb019128a57/\" />\n                        </p>\n                </li>\n                <li>\n                    <div>\n                        <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12837069/sir-run-run-shaw-hospital-school-of-medicine-zhejiang-university-warmly-welcomes-talents-abroad/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Warmly Welcomes Talents Abroad</a></h4>\n                        <div>\n                            <p>Qiushi Chair Professor; Qiushi Distinguished Scholar; ZJU 100 Young Researcher; Distinguished researcher</p>\n                            <p>No. 3, Qingchun East Road, Hangzhou, Zhejiang (CN)</p>\n                            <p>Sir Run Run Shaw Hospital Affiliated with Zhejiang University School of Medicine</p>\n                        </div>\n                    </div>\n                        <p><img src=\"https://www.nature.com/naturecareers/getasset/9d1ef9a9-3b49-447a-ad82-72ad3620962c/\" />\n                        </p>\n                </li>\n                <li>\n                    <div>\n                        <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12837067/faculty-positions-in-nonhuman-primate-research-school-of-life-sciences-westlake-university/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">Faculty Positions in Nonhuman Primate Research,  School of Life Sciences, Westlake University</a></h4>\n                        <div>\n                            <p>SLS invites applications for multiple tenure-track/tenured faculty positions at all academic ranks.</p>\n                            <p>Hangzhou, Zhejiang, China</p>\n                            <p>School of Life Sciences, Westlake University</p>\n                        </div>\n                    </div>\n                        <p><img src=\"https://www.nature.com/naturecareers/getasset/9ac11b78-5de0-4db8-9968-854002a95424/\" />\n                        </p>\n                </li>\n        </ul>\n            </div>\n                    </article>\n</div>",
  "author": "Guglielmi, Giorgia",
  "favicon": "https://www.nature.com/static/images/favicons/nature/favicon.ico",
  "source": "nature.com",
  "published": "2024-05-01",
  "ttr": 119,
  "type": "article"
}